Black smoke was seen billowing from a burning derailed rain in Tempe, Arizona, on Wednesday.
Fortunately, no injuries were reported when the Union Pacific train derailed, according to officials.
Some 90 firefighters were called on the scene of the accident that occurred at 06:00 local time (13:00 GMT).
The derailed train caused part of a bridge over the lake to collapse.
The Union Pacific train was carrying unknown but hazardous materials, reports say.
Hazmat technicians are reportedly at the scene of the accident to determine what was on the train.